Wicklow's Josh van der Flier is among Andy Farrell's selection for his pack for the Guinness Series and Autumn Nations Cup fixtures.
Former Maori All Black James Lowe is in line to make his debut for Ireland against Wales.
The Leinster winger - who qualifed through the residency rule - is one of three uncapped players included in the 34-man squad for the Autumn Nations Cup tournament.
Ulster outhalf Billy Burns and Munster centre Shane Daly are the other two.
Munster winger Keith Earls is fit again and rejoins the squad along with Ulster forward Iain Henderson - who has completed his ban.
Leinster's Jack Conan has returned to his province to rehab an injury.
After the Welsh clash, Andy Farrell's team will take on England and Georgia and a December match against either Fiji, France, Italy or Scotland.