Devin Toner has been dropped from the Ireland squad ahead of this month's Rugby World Cup in Japan.
The 67-times capped second row has been left out of Ireland's 31 man squad, with Munster's Jean Kleyn included in his place.
Schmidt has made a number of big calls, with back-up scrum half Kieran Marmion also left out, in favour of Leinster's Luke McGrath.
Connacht's Jack Carty is rewared with his man of the match performance against Wales, chosen over Ross Byrne at out-half.
Munster's Chris Farrell will travel to the Far East, with Ulster's Will Addison missing out on selection.
Addison is set to be on standby, along with his provincial teammates Jack McGrath and Jordi Murphy.
Wicklow’s Josh van der Flier is set to join Peter O’Mahony, CJ Stander, Jack Conan, Rhys Ruddock in the back row